| EAE | Experimental Autoimmune Encephalomyelitis |
| EAM | Enterprise Asset Management |
| EC2 | Amazon Elastic Compute Cloud |
| ECC | Excise Control Code |
| ECM | Enterprise Content Management |
| ECPI | Exempt Current Pension Income |
| ED | Directorate Of Enforcement |
| EDD | Estimated Date Of Delivery |
| EDI | Electronic Data Interchange |
| EDM | Electronic Dance Music |
| EDO-RAM | Extended Data Out Ram |
| EDR | Endpoint Detection And Response |
| EDS | Ehlers-Danlos Syndrome |
| EDTA | Ethylenediamine Tetraacetic Acid |
| EDUCATION | Energy Discipline Unity Confidence Aim Ttalent I Interest Opportunity Nationality |
| EFFICACY | |
| EFTPOS | Electronic Funds Transfer At Point Of Sale |
| EHS | Environmental, Health And Safety |
| EICR | Electrical Installation Condition Report |
| EID | Enrollment Id |
| EIFS | Exterior Insulation And Finish System |
| EIN | Employer Identification Number |
| ELD | Electronic Logging Device |
| ELF | Executable And Linkable Format |
| ELT | Extract, Load, Transform |
| EMM | Enterprise Mobility Management |
| EMMANUEL | God Is With Us |
| EMR | Electronic Medical Records |
| ENDANGERED | In Danger |
| ENT | Ear Nose Throat |
| EOE | Eosinophilic Esophagitis |
| EOFY | End Of Financial Year |
| EOR | Enhanced Oil Recovery |
| EPA | Environmental Protection Agency |
| EPM | Enterprise Performance Management |
| EPOS | Electronic Point Of Sale |
| EPR | Extended Producer Responsibility |
| EQUINOX | |
| EQUITY | |
| ERC | Endoscopic Retrograde Cholangiography |
| ERM | Enterprise Risk Management |
| ERV | Emergency Rescue Vehicle |
| ESA | European Space Agency |
| ESB | Enterprise Service Bus |
| ESRD | End-Stage Renal Disease |
| ETHOS | Custom" Or "Character" In Greek |
| ETRM | Energy Trading And Risk Management |
| ETSY | Expanded Truncated Structural Y |
| EUPHORIA | |
| EXAP | Exchange Applications |
| EXH | Exhaustion |
| EXPO | Exposition |